Peptide Chemistry
Peptide Chemistry
Structure, synthesis, sequence, purification, and chemical behavior of research peptides.
15 articles
24–28 min · Aug 1, 2026
PEGylation of PeptidesA technical guide to PEG conjugation chemistry, site-selective attachment, polymer architecture, analytical characterization, and quality control for PEG-modified peptides.
13 min · Jul 31, 2026
Advanced Solid-Phase Peptide SynthesisHow difficult sequences, resin aggregation, pseudoproline building blocks, double coupling, and process monitoring improve SPPS outcomes.
12 min · Jul 31, 2026
Deamidation and Isomerization in PeptidesHow asparagine and glutamine can undergo deamidation and how aspartate residues can form isoaspartate.
12 min · Jul 31, 2026
Disulfide Bonds in Peptide ChemistryHow cysteine pairing, oxidation, reduction, scrambling, and analytical mapping affect disulfide-containing peptides.
11 min · Jul 31, 2026
Hydrolysis and Peptide-Bond CleavageHow water, pH, sequence, and temperature contribute to peptide-bond and side-chain hydrolysis.
11 min · Jul 31, 2026
N-Terminal and C-Terminal Peptide ModificationsHow acetylation, amidation, pyroglutamate formation, and terminal chemistry affect mass, charge, and stability.
12 min · Jul 31, 2026
Oxidation Pathways in PeptidesHow oxygen, light, metals, peroxides, and formulation conditions can oxidize susceptible peptide residues.
12 min · Jul 31, 2026
Peptide Aggregation and Self-AssociationWhy peptides aggregate, how concentration and interfaces contribute, and which analytical methods can detect self-association.
12 min · Jul 31, 2026
Peptide Counterions and Salt FormsWhy acetate, trifluoroacetate, chloride, and other counterions matter for mass, solubility, pH, and analytical interpretation.
13 min · Jul 31, 2026
Peptide Coupling ChemistryHow carboxyl activation, coupling reagents, bases, and reaction conditions influence peptide-bond formation and side reactions.
12 min · Jul 31, 2026
Peptide Solubility FundamentalsHow charge, hydrophobicity, pH, ionic strength, concentration, and temperature influence peptide dissolution.
12 min · Jul 31, 2026
Protecting Groups in Peptide SynthesisWhy temporary and side-chain protecting groups are required and how orthogonal chemistry prevents uncontrolled reactions.
11 min · Jul 31, 2026
Resin Selection in Solid-Phase Peptide SynthesisHow linker chemistry, loading, swelling, and support properties influence peptide assembly and final C-terminal form.
11 min · Jul 31, 2026
Solid-Phase Peptide Synthesis ExplainedHow resin-based peptide assembly works, why protecting groups are required, and where synthesis-related impurities originate.
14 min · Jul 31, 2026
The Complete Guide to Peptide ChemistryA technical introduction to peptide structure, amino-acid sequence, peptide bonds, synthesis, purification, stability, and analytical characterization.